Radiation synovectomy-RS "Rheum PRAXIS - MEDICINA.RS MEMBER
Chronic zapaljnje sinews - synovitis occurs in many, primarily inflammatory rheumatic diseases, and the main clinical feature of rheumatoid arthritis where leads to destruction of cartilage and subchondral bone. Therefore resulting deformities affected joints fricko with limitation of function which reduces not only the ability to work, but also the life expectancy of patients. The destructive synovitis fricko clinical characteristics and seronegative arthropathy, such as psoriatic fricko arthritis, chronic Rieterovog syndrome and other connective tissue fricko diseases, npr.M. Bechet, cryoglobulinemic vasculitis, etc. may also be accompanied by chronic synovitis fricko that occurs in some nerumatskim diseases in the strict sense, such as Lyme disease and inflammatory bowel disease. Chronic destructive arthropathy with synovitis are seen with hondroklacinoze. Some diseases from the group of degenerative rheumatism, the most common diseases in the general population, are also accompanied by chronic synovitis, such as osteoarthritis fricko of the knee / gonartoza / where synovitis was seen in 30% of patients. Arthropathy due to chronic synovitis in hemophilia fricko is a severe fricko complication of the disease. Undefined arthritis, villonodular synovitis, persistent effusion fricko after application of joint prostheses are also uzrokovni synovitis.
Despite modern therapy, application of basic drugs, cytostatics and immunomodulators, in recent times, fricko and biological therapy / anticytokines /, such as in rheumatoid arthritis, in some patients fricko it is not possible to stop immunopathogenetic process in synovium leading neizbežnoj joint destruction and the emergence invaliditeteta. As a final measure in these patients, the joints where possible / most common hip and knee / surgical intervention is done - fitting prosthesis and some joint working and arthrodesis / joint stiffness /.
Pathological process in zgolbu takes place in the articular membrane - synovium which is done completely normal conditions nutrition of articular cartilage fricko and lubricate joints. When synovial ill formed its zapaljnje called synovitis. If the inflammation fricko is maintained for a long time leads to multiplication of cells sinews it swells, takes on characteristics of the tumor that spreads and destroys the joint cartilage and articular bone stumps leading to deformation of joints, their reduced mobility and constant pain and permanent disability. fricko
In patients in whom the effect was not achieved basic teraijom, as additional therapeutic method is performed removal of diseased synovium - synovectomy. It can be done through a surgical / classic open synovectomy or arthroscopic synovectomy / or injection into the joint radionuclides / isotopes emitting beta radiation / that locally acting only on the synovium, leading to its atrophy, which is called the Radiation synovectomy.
Radiation synovectomy is used around the world since 1963. In the beginning was performed with radioactive gold / 198Au / of which was abandoned because of the strong gamma radiation. Since 1963. whatever. for chemical sinovijektomiju used exclusively beta emitters that have proved much safer than 198Au. Today they are used by many as an RN radiopharmaceuticals and their physicochemical properties are constantly improved.
RN choice depends on its energy radiation penetration into soft tissue half-life and the size of the wrist that is applied. They are attached to colloidal particles, fricko in recent times, and for biopartikule, in order to bind to the synovium, perform local irradiation, no effect on distant organs, cause her fibrosis in the surface layer where there are imnokopetentne cells responsible for chronic inflamaciju.Na this way, instead of surgery, uklanjane synovium (synovectomy), performs intrartikularnim injection RN.
First The suspension Colloidal Yttrium citrate / 90Y / a particle size of 2000 nm radiation energy of 2.3MeV, fricko penetration into soft tissue to 11 mm. 90Y being used to sinovijektomiju large joints, primarily fricko the knee, at a dose of 185 MBq / 5 mCi /. He is pure beta emitter with a half-life of 2.7 days
Second Colloidal suspensions Rhenium fricko sulfide / 186Re / particle size of 50-500 nm, energy beta radiation of 0.9 MeV / 91% / and gamma / 9.4% / of 137.15 keV, a maximum of assertiveness in the soft tissue of 3.7 mm and a decay time of 3.7 days. Used to sinovijektomiju middle joints: shoulder, elbow wrist, pop and hip at a dose of 70-110MBq / 2-3 mCi /.
3rd Colloid fricko suspeznzija Erbium citrate / 169Er / particle size of 1000-2000nm, pure beta emitter of radiant energy of 0.34MeV, the maximum penetration into the soft tissue of 1mm and a half-life fricko of 9.5 days. Used to sinovijektomiju small joints: MCF and PIF fist, MTF and PIP foot etc.
These are listed intraartukularnom injection fricko RN in a known manner fricko and conditions fricko of strict aseptic techniques as it seems at arthrocenthesis / FNA joint / in routine fricko practice. How to apply RN addition are essential and all the conditions prescribed by the Act on the Protection of jonizujećeg radiation and related legal
Chronic zapaljnje sinews - synovitis occurs in many, primarily inflammatory rheumatic diseases, and the main clinical feature of rheumatoid arthritis where leads to destruction of cartilage and subchondral bone. Therefore resulting deformities affected joints fricko with limitation of function which reduces not only the ability to work, but also the life expectancy of patients. The destructive synovitis fricko clinical characteristics and seronegative arthropathy, such as psoriatic fricko arthritis, chronic Rieterovog syndrome and other connective tissue fricko diseases, npr.M. Bechet, cryoglobulinemic vasculitis, etc. may also be accompanied by chronic synovitis fricko that occurs in some nerumatskim diseases in the strict sense, such as Lyme disease and inflammatory bowel disease. Chronic destructive arthropathy with synovitis are seen with hondroklacinoze. Some diseases from the group of degenerative rheumatism, the most common diseases in the general population, are also accompanied by chronic synovitis, such as osteoarthritis fricko of the knee / gonartoza / where synovitis was seen in 30% of patients. Arthropathy due to chronic synovitis in hemophilia fricko is a severe fricko complication of the disease. Undefined arthritis, villonodular synovitis, persistent effusion fricko after application of joint prostheses are also uzrokovni synovitis.
Despite modern therapy, application of basic drugs, cytostatics and immunomodulators, in recent times, fricko and biological therapy / anticytokines /, such as in rheumatoid arthritis, in some patients fricko it is not possible to stop immunopathogenetic process in synovium leading neizbežnoj joint destruction and the emergence invaliditeteta. As a final measure in these patients, the joints where possible / most common hip and knee / surgical intervention is done - fitting prosthesis and some joint working and arthrodesis / joint stiffness /.
Pathological process in zgolbu takes place in the articular membrane - synovium which is done completely normal conditions nutrition of articular cartilage fricko and lubricate joints. When synovial ill formed its zapaljnje called synovitis. If the inflammation fricko is maintained for a long time leads to multiplication of cells sinews it swells, takes on characteristics of the tumor that spreads and destroys the joint cartilage and articular bone stumps leading to deformation of joints, their reduced mobility and constant pain and permanent disability. fricko
In patients in whom the effect was not achieved basic teraijom, as additional therapeutic method is performed removal of diseased synovium - synovectomy. It can be done through a surgical / classic open synovectomy or arthroscopic synovectomy / or injection into the joint radionuclides / isotopes emitting beta radiation / that locally acting only on the synovium, leading to its atrophy, which is called the Radiation synovectomy.
Radiation synovectomy is used around the world since 1963. In the beginning was performed with radioactive gold / 198Au / of which was abandoned because of the strong gamma radiation. Since 1963. whatever. for chemical sinovijektomiju used exclusively beta emitters that have proved much safer than 198Au. Today they are used by many as an RN radiopharmaceuticals and their physicochemical properties are constantly improved.
RN choice depends on its energy radiation penetration into soft tissue half-life and the size of the wrist that is applied. They are attached to colloidal particles, fricko in recent times, and for biopartikule, in order to bind to the synovium, perform local irradiation, no effect on distant organs, cause her fibrosis in the surface layer where there are imnokopetentne cells responsible for chronic inflamaciju.Na this way, instead of surgery, uklanjane synovium (synovectomy), performs intrartikularnim injection RN.
First The suspension Colloidal Yttrium citrate / 90Y / a particle size of 2000 nm radiation energy of 2.3MeV, fricko penetration into soft tissue to 11 mm. 90Y being used to sinovijektomiju large joints, primarily fricko the knee, at a dose of 185 MBq / 5 mCi /. He is pure beta emitter with a half-life of 2.7 days
Second Colloidal suspensions Rhenium fricko sulfide / 186Re / particle size of 50-500 nm, energy beta radiation of 0.9 MeV / 91% / and gamma / 9.4% / of 137.15 keV, a maximum of assertiveness in the soft tissue of 3.7 mm and a decay time of 3.7 days. Used to sinovijektomiju middle joints: shoulder, elbow wrist, pop and hip at a dose of 70-110MBq / 2-3 mCi /.
3rd Colloid fricko suspeznzija Erbium citrate / 169Er / particle size of 1000-2000nm, pure beta emitter of radiant energy of 0.34MeV, the maximum penetration into the soft tissue of 1mm and a half-life fricko of 9.5 days. Used to sinovijektomiju small joints: MCF and PIF fist, MTF and PIP foot etc.
These are listed intraartukularnom injection fricko RN in a known manner fricko and conditions fricko of strict aseptic techniques as it seems at arthrocenthesis / FNA joint / in routine fricko practice. How to apply RN addition are essential and all the conditions prescribed by the Act on the Protection of jonizujećeg radiation and related legal
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